If you're not going to use the amps natural tube distortion, you could go with a solid state amp. For me, the distortion from the tubes itself is EVERYTHING. I have a few pedals, before the preamp and in the effects loop, but most are all just additions to one main theme, and that is - clean channel for clean sounds, drive channel for standard rock rhythm sounds, and a tube screamer in the front to add to the natural drive channel for lead tone. So, your rhythm is the amp alone and the lead is a combination of the pedal and the amp. Works for me.
as a side note - my favorite dream pedal is the Xotic SP compressor which ( besides the tuner ) is the first pedal in my chain. Everything is after that. I never turn it off. Everything just sounds sweeter when that pedal is on.
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