By the time SRV recorded his last album, "In Step," he was using a whole bunch of amps simultaneously. After a small amount of Googling, I found this rundown of his various setups; you might find this interesting, Bill. Of course, you'd need a small semi and a team of roadies to deal with all of this gear!
www.angelfire.com/ks/keithcjulian/srvfaq5a.htm
I have two pieces of Line 6 gear that can give you two different digital amp models (of your choice) simultaneously and each can have their own effects chain and be routed to separate cabinets: the Vetta 2x12 combo (which they discontinued a couple of years ago) and the Pod HD500, which is a preamp/multi-effects floorboard that can be used as a direct unit or with power amps and cabinets. All of the patches I made on my Vetta use two different amp models, one per speaker. Of course the effect is much more dynamic when you use separate cabinets. But I never spent too much time mixing clean and dirty amp models. I always dug what Alex Lifeson did with that kind of thing (even though I'm not really a Rush fan), but it's not something I was ever interested in pursuing for myself.
To me, getting a distorted lead sound that has enough definition with the right amount of higher frequency bite depends on several factors, but most importantly it's a guitar with nicely voiced pickups and an amplifier that's capable of doing that. I've found that playing lead with a single coil pickup sound and a guitar with a bolt-on neck works best; the neck provides a faster attack and the slightly scooped midrange of a single coil keeps things from getting too mushy. But you can do it with humbuckers and through-body or glue-on necks too, it's just a matter of EQing and keeping the gain (or drive) down low enough to keep things from getting muddy. So many factors come into play in the realm of guitar tone, it comes down to a lot of experimenting with a lot of gear combinations.
Anyway, good luck on your tone quest!
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